Abstract
Pro-inflammatory chemokines are important mediators of inflammation and autoimmune injury. The spatial and temporal expression of chemokines and chemokine receptors in the nephritic kidney suggests that targeting the chemokine system may represent a valuable approach for anti-inflammatory therapy of lupus nephritis. In this review we summarize the available data on the pathogenic role of chemokines and chemokine receptors in lupus nephritis and particularly focus on epidemiological data in lupus patients and interventional studies with chemokine or chemokine receptor antagonists in experimental lupus.
Keywords: Chemokine, chemokine receptors, systemic lupus erythematosus, MRL/lpr mouse, leukocyte recruitment, kidney, polymorphism
Endocrine, Metabolic & Immune Disorders - Drug Targets
Title: Blockade of Chemokine-Mediated Tissue Injury in Lupus Nephritis
Volume: 6 Issue: 4
Author(s): Volker Vielhauer and Hans-Joachim Anders
Affiliation:
Keywords: Chemokine, chemokine receptors, systemic lupus erythematosus, MRL/lpr mouse, leukocyte recruitment, kidney, polymorphism
Abstract: Pro-inflammatory chemokines are important mediators of inflammation and autoimmune injury. The spatial and temporal expression of chemokines and chemokine receptors in the nephritic kidney suggests that targeting the chemokine system may represent a valuable approach for anti-inflammatory therapy of lupus nephritis. In this review we summarize the available data on the pathogenic role of chemokines and chemokine receptors in lupus nephritis and particularly focus on epidemiological data in lupus patients and interventional studies with chemokine or chemokine receptor antagonists in experimental lupus.
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Cite this article as:
Vielhauer Volker and Anders Hans-Joachim, Blockade of Chemokine-Mediated Tissue Injury in Lupus Nephritis, Endocrine, Metabolic & Immune Disorders - Drug Targets 2006; 6 (4) . https://dx.doi.org/10.2174/187153006779025739
DOI https://dx.doi.org/10.2174/187153006779025739 |
Print ISSN 1871-5303 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3873 |
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