Anti-Bacterial Drug Discovery Using Systems Biology

K.   D.   Kumble

Abstract

The pipeline for new antibacterials is bleak despite the fact that infectious diseases account for a quarter of all worldwide deaths due to disease. Bacteria are ideal organisms for a systems biology approach to understanding pathogenesis by combined use of genomic technologies and computer algorithms. This approach can be applied to identify control points in molecular networks, which could be targets for novel drugs.

Keywords: Genomics, systems biology, molecular networks, antibacterials, pathogens

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