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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Small Molecule and Biologic Inhibitors of Hepatitis C Virus: A Symbiotic Approach

Author(s): A. M. Del Vecchio and R. T. Sarisky

Volume 6, Issue 11, 2006

Page: [1263 - 1268] Pages: 6

DOI: 10.2174/138955706778742786

Price: $65


Chronic infection with hepatitis C virus (HCV) remains a global health concern. Using both in vitro and cellbased assays, a series of small molecule agents specific for the viral RNA-dependent RNA polymerase have been shown to interfere with viral RNA replication. Although no agents targeting this viral enzyme have demonstrated sustained efficacy in infected patients as measured by reduction in viral load at 72 weeks post-treatment, proof-of-concept has been achieved in the clinic. A comprehensive account of the structure-activity relationship for nucleoside and non-nucleoside inhibitors of HCV polymerase, as well as consideration of early discovery biologic approaches targeting NS5B are reviewed.

Keywords: Nonstructural protein 5B (NS5B), RNA-dependent RNA polymerase (RdRp), hepatitis C virus (HCV), nonnucleoside inhibitors (NNI), nucleoside inhibitors, acyl pyrrolidine, benzofuran

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