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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Synthesis and Biological Activity of Akt/PI3K Inhibitors

Author(s): C. Redaelli, F. Granucci, L. De Gioia and L. Cipolla

Volume 6, Issue 10, 2006

Page: [1127 - 1136] Pages: 10

DOI: 10.2174/138955706778560139

Price: $65


Phosphatidylinositol 3-kinase (PI3K) and serine/threonine protein kinase B (PKB or Akt) pathways regulate important cellular processes and are related to a number of human pathologies, such as cancer. The development of kinase inhibitors, with particular attention to small molecule analogues of natural phosphoinositides for pathway interruption and therapeutic applications will be reviewed.

Keywords: Kinases, Akt, PI3K, cancer, kinase inhibitors, allosteric inhibitors, phosphatidylinositol, phosphatidylinositol analogues

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