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Current Vascular Pharmacology


ISSN (Print): 1570-1611
ISSN (Online): 1875-6212

The Etiology of Hypertension in the Metabolic Syndrome Part Three: The Regulation and Dysregulation of Blood Pressure

Volume 4, Issue 4, 2006

Page: [321 - 348] Pages: 28

DOI: 10.2174/157016106778521643

Price: $65


To understand blood pressure is regulated, and how this regulation is disturbed in hypertension, we need to understand how blood volume is regulated and how the distribution of that volume across the vascular tree is regulated. Here we review the literature on blood volume regulation and how it is disturbed in the pre-diabetic and diabetic state. We also provide a comprehensive overview of vascular dysfunction, discussing the key mechanisms, mediators and pathways which are involved. In particular, we focus on the key concept of endothelial dysfunction and how this has shaped our understanding of hypertension.

Keywords: Metabolic syndrome, diabetes, hypertension, obesity, insulin resistance, volume homeostasis, endothelial dysfunction, kidney, sympathetic nervous system, renin-angiotensin system

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