Application of Bioreduction by Microorganisms in the Enantioselective Synthesis of Alpha-Substituted-1-Phenylethanols

Title: Application of Bioreduction by Microorganisms in the Enantioselective Synthesis of Alpha-Substituted-1-Phenylethanols

Volume: 3 Issue: 8

Author(s): Leandro H. Andrade, Roberta Polak, Andre L. M. Porto, Iracema H. Schoenlein-Crusius and Joao V. Comasseto

Affiliation:

Keywords: Bioreduction, hydrolysis, ketone, chiral alcohol, fungus

Abstract: The enantioselective bioreduction of alpha-substituted-acetophenones 1,2 was carried out with cells of fungi to give the corresponding chiral alcohols in good yield and high enantioselectivity (up to 99%). The chiral alcohols 3 and 4 obtained by this methodology are important intermediates for the asymmetric syntheses of chiral drugs. The enantioselectivity presented by several fungal strains was anti-Prelog.

Cite this article as:

Andrade H. Leandro, Polak Roberta, Porto L. M. Andre, Schoenlein-Crusius H. Iracema and Comasseto V. Joao, Application of Bioreduction by Microorganisms in the Enantioselective Synthesis of Alpha-Substituted-1-Phenylethanols, Letters in Organic Chemistry 2006; 3 (8) . https://dx.doi.org/10.2174/157017806778559509