Generic placeholder image

Letters in Organic Chemistry


ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Application of Bioreduction by Microorganisms in the Enantioselective Synthesis of Alpha-Substituted-1-Phenylethanols

Author(s): Leandro H. Andrade, Roberta Polak, Andre L. M. Porto, Iracema H. Schoenlein-Crusius and Joao V. Comasseto

Volume 3, Issue 8, 2006

Page: [613 - 618] Pages: 6

DOI: 10.2174/157017806778559509

Price: $65


The enantioselective bioreduction of alpha-substituted-acetophenones 1,2 was carried out with cells of fungi to give the corresponding chiral alcohols in good yield and high enantioselectivity (up to 99%). The chiral alcohols 3 and 4 obtained by this methodology are important intermediates for the asymmetric syntheses of chiral drugs. The enantioselectivity presented by several fungal strains was anti-Prelog.

Keywords: Bioreduction, hydrolysis, ketone, chiral alcohol, fungus

Rights & Permissions Print Export Cite as
© 2023 Bentham Science Publishers | Privacy Policy