Generic placeholder image

Letters in Drug Design & Discovery


ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Comparison of Noradrenergic Receptor Distribution in the Hippocampus of Rodents and Humans: Implications for Differential Drug Response

Author(s): Patricia Szot

Volume 3, Issue 9, 2006

Page: [645 - 652] Pages: 8

DOI: 10.2174/157018006778341200

Price: $65


The therapeutic efficacy of most pharmacological agents is generally established first in rodents and then in humans. To better extrapolate the effects of pharmacological agents in rodents to humans it is important to know how similar (or dissimilar) systems are between rodents and humans. This review examines the differences in the localization of the noradrenergic receptors in the hippocampus of humans and rodents. The differences in receptor localization could have major implications for the actions (or side effects) of noradrenergic agents in humans.

Keywords: Norepinephrine, Adrenoreceptors, Hippocampus, Alpha receptors, Beta receptors

Rights & Permissions Print Export Cite as
© 2023 Bentham Science Publishers | Privacy Policy