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Protein & Peptide Letters


ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Interaction Partners of the PDZ Domain of Erbin

Author(s): Angelika Ress and Karin Moelling

Volume 13 , Issue 9 , 2006

Page: [877 - 881] Pages: 5

DOI: 10.2174/092986606778256126

Price: $65


In order to identify proteins that bind to the PDZ domain of Erbin, we tested the C-termini of several proteins in a yeast two-hybrid assay. ErbB2, APC, β-catenin, c-Rel and HTLV-1 Tax were identified as ligands of the PDZ domain of Erbin. The interactions were verified by co-immunoprecipitation experiments. These findings demonstrate the promiscuity of the PDZ domain of Erbin.

Keywords: Erbin, PDZ domain, ErbB2, APC, c-Rel, HTLV-1 Tax

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