Cytotoxicity and Antiviral Activity of Palladium(II) Quinolylmethylphosphonate Complexes. Synthesis of Acetate Complexes

Title: Cytotoxicity and Antiviral Activity of Palladium(II) Quinolylmethylphosphonate Complexes. Synthesis of Acetate Complexes

Volume: 3 Issue: 8

Author(s): Ljerka Tusek-Bozic, Vesna Cmrecki, Jan Balzarini and Erik De Clercq

Affiliation:

Keywords: Palladium complex, Acetate complex, Phosphonate, Cytotoxicity, Antiviral activity

Abstract: Palladium(II) acetate complexes with diethyl 8-quinolylmethylphosphonate (8-dqmp) and monoethyl 2- quinolylmethylphosphonate (2-Hmqmp) were synthesized and evaluated for their cytotoxic and antiviral activity in vitro in different cell lines. Structure-activity relationship studies comprise acetate and chloro complexes of the phosphonate ligands. Cell growth inhibitory effects in micro molar range were observed for the dichloro adduct and acetate bridged dimer of 8-dqmp.

Cite this article as:

Tusek-Bozic Ljerka, Cmrecki Vesna, Balzarini Jan and De Clercq Erik, Cytotoxicity and Antiviral Activity of Palladium(II) Quinolylmethylphosphonate Complexes. Synthesis of Acetate Complexes, Letters in Drug Design & Discovery 2006; 3 (8) . https://dx.doi.org/10.2174/157018006778194772