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Letters in Drug Design & Discovery


ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Cytotoxicity and Antiviral Activity of Palladium(II) Quinolylmethylphosphonate Complexes. Synthesis of Acetate Complexes

Author(s): Ljerka Tusek-Bozic, Vesna Cmrecki, Jan Balzarini and Erik De Clercq

Volume 3, Issue 8, 2006

Page: [528 - 533] Pages: 6

DOI: 10.2174/157018006778194772

Price: $65


Palladium(II) acetate complexes with diethyl 8-quinolylmethylphosphonate (8-dqmp) and monoethyl 2- quinolylmethylphosphonate (2-Hmqmp) were synthesized and evaluated for their cytotoxic and antiviral activity in vitro in different cell lines. Structure-activity relationship studies comprise acetate and chloro complexes of the phosphonate ligands. Cell growth inhibitory effects in micro molar range were observed for the dichloro adduct and acetate bridged dimer of 8-dqmp.

Keywords: Palladium complex, Acetate complex, Phosphonate, Cytotoxicity, Antiviral activity

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