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Letters in Drug Design & Discovery


ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Analysis of Brostallicin Effect on Different Human Gastrointestinal Cancer Cell Lines

Author(s): A. I. Scovassi, C. Gorrini, W. Pastori and M. Ciomei

Volume 3, Issue 8, 2006

Page: [524 - 527] Pages: 4

DOI: 10.2174/157018006778194682

Price: $65


Brostallicin, a specific adenine-thymine minor groove binder belonging to a new class of distamycin A-derivatives, proved to be active in vitro against a panel of human tumor cell lines. We demonstrated here the cytotoxic and apoptotic potential of this compound on gastric and colon cancer cell lines with either wt or mutated p53.

Keywords: Apoptosis, Brostallicin, Colon carcinoma cell lines, Gastric cancer cell lines, p53

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