Analysis of Brostallicin Effect on Different Human Gastrointestinal Cancer Cell Lines

Title: Analysis of Brostallicin Effect on Different Human Gastrointestinal Cancer Cell Lines

Volume: 3 Issue: 8

Author(s): A. I. Scovassi, C. Gorrini, W. Pastori and M. Ciomei

Affiliation:

Keywords: Apoptosis, Brostallicin, Colon carcinoma cell lines, Gastric cancer cell lines, p53

Abstract: Brostallicin, a specific adenine-thymine minor groove binder belonging to a new class of distamycin A-derivatives, proved to be active in vitro against a panel of human tumor cell lines. We demonstrated here the cytotoxic and apoptotic potential of this compound on gastric and colon cancer cell lines with either wt or mutated p53.

Cite this article as:

Scovassi I. A., Gorrini C., Pastori W. and Ciomei M., Analysis of Brostallicin Effect on Different Human Gastrointestinal Cancer Cell Lines, Letters in Drug Design & Discovery 2006; 3(8) . https://dx.doi.org/10.2174/157018006778194682