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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Chiral Amino-Amides as Solution Phase and Immobilized Ligands for the Catalytic Asymmetric Alkylation of Aromatic Aldehydes

Author(s): Alessandra Silvani, Alessandro Sacchetti, Daniele Passarella, Bruno Danieli and Giordano Lesma

Volume 3, Issue 6, 2006

Page: [430 - 436] Pages: 7

DOI: 10.2174/157017806777828529

Price: $65

Abstract

Novel chiral amino-amide 9-keto-bispidines are investigated as ligands in the addition reaction of diethylzinc to aromatic aldehydes. The ligands are easily obtained by a single step procedure starting from commercially available products. Selected ligands were also supported onto different insoluble resins in order to test their activity as heterogeneous catalysts.

Keywords: diethylzinc, bispidine, 3,7-diazabicyclo[3.3.1]nonane, asymmetric synthesis, Chiral ligand


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