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Letters in Organic Chemistry


ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Microwave-Promoted Facile and Rapid Solvent-Free Synthesis Procedure for the Efficient Synthesis of 3,4-Dihydropyrimidin-2(1H)-Ones and -Thiones Using ZrO2/SO42- as a Reusable Heterogeneous Catalyst

Author(s): Muthuvel R. Ezhilarasi, Ramalingam Govindaraju, Jeyaraman Thanusu, Vijayakumar Kanagarajan, Purushothaman Sureshkumar and Mannathusamy Gopalakrishnan

Volume 3, Issue 6, 2006

Page: [484 - 488] Pages: 5

DOI: 10.2174/157017806777828493

Price: $65


Sulfated zirconia (ZrO2/SO4 2-) solid superacid has been proved to be an efficient reusable heterogeneous catalyst for three-component one-pot cyclocondensation reaction of β-dicarbonyl compounds and urea/thiourea with structurally diverse aromatic aldehydes in solvent-free conditions to furnish the corresponding 3,4-dihydropyrimidin-2(1H)-ones and -thiones in good to excellent yields both under microwave irradiation and thermal conditions.

Keywords: green chemistry, microwave irradiation, dihydropyrimidinones, sulfated zirconia, Biginelli reaction

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