Generic placeholder image

Recent Patents on Anti-Cancer Drug Discovery

Editor-in-Chief

ISSN (Print): 1574-8928
ISSN (Online): 2212-3970

Recent Developments to Improve the Efficacy of Cytotoxic Nucleoside Analogues

Author(s): Lars P. Jordheim, Carlos M. Galmarini and Charles Dumontet

Volume 1, Issue 2, 2006

Page: [163 - 170] Pages: 8

DOI: 10.2174/157489206777442205

Price: $65

Abstract

Cytotoxic nucleoside analogues are clinically important anticancer drugs. The newer member of this family, gemcitabine, has shown great activity in solid tumors and thus enlarged the spectra of malignancies treated by this family of molecules. However, the clinical use of nucleoside analogues is limited by important side-effects and primary or acquired drug resistance, and there is an unmet medical need for the development of new molecules and technologies allowing a suitable treatment of cancer patients with these agents. In this article we will review literature data and patents concerning (i) the recent development of some novel nucleoside analogues, (ii) oral formulations for cytotoxic nucleoside analogues, (iii) strategies to circumvent acquired resistance to nucleoside analogues, and (iv) gene therapy strategies used to increase cytotoxicity of nucleoside analogues.

Keywords: Nucleoside analogues, Pronucleotides, Gene therapy, CP-4055, CP-4126, MB-7133, CYC-682, Ethynylcytidine, OSI-3876, NEO-6002


Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy