Efficient Diastereoselective Titanium(IV) Reductive Amination of Ketones

Title: Efficient Diastereoselective Titanium(IV) Reductive Amination of Ketones

Volume: 3 Issue: 5

Author(s): Chanaz Salmi, Yves Letourneux and Jean M. Brunel

Affiliation:

Keywords: Titanium, Reductive amination, Ketones, Secondary amines, Imines, Diastereoselectivity

Abstract: An efficient method for the diastereoselective synthesis of various secondary amines through a titanium(IV) isopropoxide-mediated reductive amination reaction of ketones is reported. Thus, a series of different ketones and (R)-Phenylethylamine were involved leading to the expected products in moderate to excellent yields and importantly in diastereoselectivities up to 100% in one case.

Cite this article as:

Salmi Chanaz, Letourneux Yves and Brunel M. Jean, Efficient Diastereoselective Titanium(IV) Reductive Amination of Ketones, Letters in Organic Chemistry 2006; 3 (5) . https://dx.doi.org/10.2174/157017806776611971