Synthesis of C1-C6 Fragment of Caribenolide I

Title: Synthesis of C1-C6 Fragment of Caribenolide I

Volume: 3 Issue: 5

Author(s): Matar Seck, Blandine Seon-Meniel, Jean-Christophe Jullian, Xavier Franck, Reynald Hocquemiller and Bruno Figadere

Affiliation:

Keywords: Amphidinolide, macrolide, antitumor, cytotoxic activity, aldolisation, oxazolidinones, oxazolidin-2-thiones

Abstract: Stereoselective synthesis of C1-C6 fragment of caribenolide I, a potent antitumour macrolide isolated from a marine dinoflagellate Amphidinium sp. is described. The key step relies on an asymmetric aldol reaction for control the absolute configurations of C2 and C3 stereogenic centers (caribenolide I numbering).

Cite this article as:

Seck Matar, Seon-Meniel Blandine, Jullian Jean-Christophe, Franck Xavier, Hocquemiller Reynald and Figadere Bruno, Synthesis of C1-C6 Fragment of Caribenolide I, Letters in Organic Chemistry 2006; 3 (5) . https://dx.doi.org/10.2174/157017806776611818