Abstract
An improved approach has been found to carry out the Biginelli reaction for the synthesis of 3,4- dihydropyrimidin- 2(1H)-one derivatives. This synthesis was performed in the presence of hydrochloric acid and β-cyclodextrin in ethanol solution. Compared with the classical Biginelli reaction conditions, this new approach has the advantage of excellent yields and short reaction time.
Keywords: Biginelli reaction, Dihydropyrimidinones, β-cyclodextrin, One-pot, Synthesis
Letters in Organic Chemistry
Title: One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Using Hydrochloric Acid- β-Cyclodextrin- Combined Catalysts
Volume: 3 Issue: 3
Author(s): Genxiang Luo, Chunsheng Liu, Haixia Zhou and Miao He
Affiliation:
Keywords: Biginelli reaction, Dihydropyrimidinones, β-cyclodextrin, One-pot, Synthesis
Abstract: An improved approach has been found to carry out the Biginelli reaction for the synthesis of 3,4- dihydropyrimidin- 2(1H)-one derivatives. This synthesis was performed in the presence of hydrochloric acid and β-cyclodextrin in ethanol solution. Compared with the classical Biginelli reaction conditions, this new approach has the advantage of excellent yields and short reaction time.
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Cite this article as:
Luo Genxiang, Liu Chunsheng, Zhou Haixia and He Miao, One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Using Hydrochloric Acid- β-Cyclodextrin- Combined Catalysts, Letters in Organic Chemistry 2006; 3 (3) . https://dx.doi.org/10.2174/157017806775789985
DOI https://dx.doi.org/10.2174/157017806775789985 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
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