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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Stereoselective Total Synthesis of (+)-Sedamine

Author(s): Jagat C. Borah, Joshodeep Boruwa and Nabin C. Barua

Volume 3, Issue 2, 2006

Page: [140 - 142] Pages: 3

DOI: 10.2174/157017806775224297

Price: $65

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Abstract

A highly efficient stereoselective total synthesis of piperidine alkaloid (+)-sedamine has been described utilizing two regioselective ring opening reactions of epoxide with vinyl metallic reagent and a ring closing metathesis reaction as the key steps.

Keywords: (+)-sedamine, vinylmetallic reagent, ADH, regioselective epoxide opening, RCM


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