Abstract
Glutamate is one of the major neurotrasmitters in mammalian brain and changes in its concentration have been associated with a number of neurological disorders, including neurodegenerative, cerebrovascular diseases and epilepsy. Moreover, recently a possible role for glutamatergic system dysfunction has been suggested also in the peripheral nervous system. This chapter will revise the current knowledge in the distribution of glutamate and of its receptors and transporters in the central nervous system.
Keywords: Central nervous system, excitatory, excitotoxicity, glutamate, peripheral nervous system, receptors, transporters, glutamatergic neurotransmission, cerebrovascular diseases, epilepsy
Current Medicinal Chemistry
Title: The Glutamatergic Neurotransmission in the Central Nervous System
Volume: 19 Issue: 9
Author(s): P. Marmiroli and G. Cavaletti
Affiliation:
Keywords: Central nervous system, excitatory, excitotoxicity, glutamate, peripheral nervous system, receptors, transporters, glutamatergic neurotransmission, cerebrovascular diseases, epilepsy
Abstract: Glutamate is one of the major neurotrasmitters in mammalian brain and changes in its concentration have been associated with a number of neurological disorders, including neurodegenerative, cerebrovascular diseases and epilepsy. Moreover, recently a possible role for glutamatergic system dysfunction has been suggested also in the peripheral nervous system. This chapter will revise the current knowledge in the distribution of glutamate and of its receptors and transporters in the central nervous system.
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Cite this article as:
Marmiroli P. and Cavaletti G., The Glutamatergic Neurotransmission in the Central Nervous System, Current Medicinal Chemistry 2012; 19 (9) . https://dx.doi.org/10.2174/092986712799462711
DOI https://dx.doi.org/10.2174/092986712799462711 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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