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Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Resveratrol in Cancer: Cellular and Mitochondrial Consequences of Proton Transport Inhibition

Author(s): Guillermo Lopez-Lluch, Sara Santa Cruz-Calvo and Placido Navas

Volume 18, Issue 10, 2012

Page: [1338 - 1344] Pages: 7

DOI: 10.2174/138161212799504849

Price: $65


Transformed cells suffer several changes leading to the increase of protective mechanisms and show a metabolic profile in accordance with higher proliferative capacity. In these mechanisms, changes in mitochondrial activity cause a higher glycolytic metabolism in detriment of oxidative phosphorylation. In these changes, H+-ATPase regulation seems to be importantly involved. During the last years, polyphenols and specially the stilbene resveratrol and related members of its family have been studied because they are able to affect tumour cell growth and cancer progression. Among the different effects induced by resveratrol, inhibition of H+-ATPase seems to be one important mechanism in its effect on cancer progression. Further, an ectopic H+-ATPase located in the outer surface of plasma membrane has been recently involved in cancer progression and angiogenesis. In this article we review the latest findings about resveratrol inhibition of H+-ATPase and its importance in tumour cell growth and cancer progression.

Keywords: Resveratrol, polyphenols, H+-ATPase, mitochondria, angiogenesis, cell growth, transformed cells, glycolytic metabolism, oxidative phosphorylation, cancer progression

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