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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Mechanisms of Action and Targets for Actual and Future Antiplatelet Drugs

Author(s): Kathleen Freson, Chantal Thys, Christine Wittevrongel and Chris V. Geet

Volume 6, Issue 6, 2006

Page: [719 - 726] Pages: 8

DOI: 10.2174/138955706777435661

Price: $65

Abstract

Platelets are key players in arterial thrombosis and have become important targets in the primary and secondary prevention of atherothrombosis. Antiplatelet drugs are primarily directed against platelets and inhibit platelet activation by a number of different mechanisms. They are used for the prevention and treatment of thrombotic processes, especially in the arterial vascular system. Antiplatelet drugs in clinical use and experimental drugs are discussed.

Keywords: cyclooxygenase, GPIIb/IIIa antagonists, Ticlopidine, monoclonal antibody, Thrombin Receptors


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