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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Sphingolipids as Targets for Microbial Infections

Author(s): Travis J. McQuiston, Charles Haller and Maurizio D. Poeta

Volume 6, Issue 6, 2006

Page: [671 - 680] Pages: 10

DOI: 10.2174/138955706777435634

Price: $65


Sphingolipids had long been regarded as merely structural components of eukaryotic cellular membranes. Research has discovered sphingolipids to have crucial roles in cellular processes as bioactive molecules. Lately, there has also been an increased interest in sphingolipids and sphingolipid-metabolizing enzymes as mediators of microbial pathogenicity and as potential targets for the development of new therapeutics. This minireview will provide a comprehensive analysis of sphingolipid pathways in mammalian and microbial cells, highlighting their uniqueness and discussing their potential as therapeutic targets for microbial infections.

Keywords: longevity-assurance gene 1, sphingomyelin synthase (SMS), fungal sphingolipid, Kinetoplastid protozoa, SPH kinase

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