Neurophysiological Alterations in the Prepsychotic Phases

Title: Neurophysiological Alterations in the Prepsychotic Phases

Volume: 18 Issue: 4

Author(s): Nicolas A. Crossley, Miguel Constante, Paolo Fusar-Poli and Elvira Bramon

Affiliation:

Keywords: Prodrome, psychosis, EEG, ERP, Magnetoencephalography, pre-psychotic phase, schizophrenia, healthy controls, Mismatch negativity (MMN), Comprehensive Assessment of At-Risk Mental States (CAARMS)

Abstract: Electroencephalography and Magnetoencephalography have provided valuable information about the brain functioning in psychosis. In the last few years, authors have demonstrated that there are neurophysiological alterations already in the prodromal period, before the development of psychosis. This makes them promising tools for predicting a future transition to psychosis. In this paper we review the latest studies using event-related potentials (ERP) in subjects clinically at high-risk of developing psychosis. We particularly focus in the P300, Mismatch-Negativity (MMN) and P50 paradigms, discussing the main findings, but also the limitations and challenges in electrophysiological studies in this population.

Cite this article as:

A. Crossley Nicolas, Constante Miguel, Fusar-Poli Paolo and Bramon Elvira, Neurophysiological Alterations in the Prepsychotic Phases, Current Pharmaceutical Design 2012; 18(4) . https://dx.doi.org/10.2174/138161212799316307