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Endocrine, Metabolic & Immune Disorders - Drug Targets

Editor-in-Chief

ISSN (Print): 1871-5303
ISSN (Online): 2212-3873

Coagulation and Sepsis

Author(s): F. R. Machado and E. Silva

Volume 6, Issue 2, 2006

Page: [175 - 182] Pages: 8

DOI: 10.2174/187153006777442369

Price: $65

Abstract

Sepsis is a complex disease and coagulation derangements are part of this context. The inflammatory storm is ultimately responsible for coagulation derangements. It is characterized by exacerbated coagulation, impaired anticoagulation and decreased fibrin removal. These derangements are implicated in the generation of microcirculation thrombosis, with deposition of microclots and obstruction of circulation, impairing blood flow and contributing to tissue hypoperfusion and consequently, organ dysfunction. This review will address the main issues regarding coagulation disorders in the context of sepsis.

Keywords: Sepsis, coagulation, fibrinolysis, activated protein C, antithrombin, tissue factor


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