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Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Extrapituitary Actions of GnRH Antagonists: Prospects for in vitro Fertilization Programs

Author(s): Gianna Gabriella Impicciatore and Gian Mario Tiboni

Volume 18, Issue 3, 2012

Page: [264 - 269] Pages: 6

DOI: 10.2174/138161212799040358

Price: $65


Gonadotropin-releasing hormone antagonists (GnRH-ant) are routinely used to prevent premature luteinizing hormone (LH) surges in women undergoing in vitro fertilization (IVF) programs. GnRH-ant act by competitively binding GnRH receptors (GnRHr), leading to rapid pituitary suppression. GnRH-ant can also block extrapituitary GnRHr, including those present in ovary, placenta, and endometrium. A full understanding of the functional roles played by extrapitutary GnRHr, along with a better characterization of the possible reproductive consequences of their blockage may aid the refinement of controlled ovarian stimulation (COS) protocols using GnRHant. This review summarizes current research in the area, especially focusing on the possible impact of GnRH-ant on steroidogenesis, folliculogenesis and endometrial receptivity.

Keywords: GnRH, GnRH antagonists, Steroidogenesis, Folliculogenesis, Endometrium, In Vitro Fertilization, ovary, placenta, controlled ovarian stimulation (COS), endometrial receptivity

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