Abstract
This work is focused on SFTI-1, a member of the Bowman-Birk family of inhibitors. This 14 amino acid cyclic peptide exhibits several features i.e. compact rigidity, well-defined structure and small size that could result in a wide range of potential applications. Some examples of engineering of the specificity of this inhibitor along with structure - activity relationships will be discussed herein. Additionally, potential uses of STFI-1 and its analogs as pharmaceutical agents will be described.
Keywords: SFTI-1, inhibitor, serine proteinases, peptidomimetics, peptomers, analogs, pharmaceutical agents, cytotoxicity, trypsin, chymotrypsin
Current Pharmaceutical Design
Title: Sunflower Trypsin Inhibitor 1 as a Molecular Scaffold for Drug Discovery
Volume: 17 Issue: 38
Author(s): Adam Lesner, Anna Legowska, Magdalena Wysocka and Krzysztof Rolka
Affiliation:
Keywords: SFTI-1, inhibitor, serine proteinases, peptidomimetics, peptomers, analogs, pharmaceutical agents, cytotoxicity, trypsin, chymotrypsin
Abstract: This work is focused on SFTI-1, a member of the Bowman-Birk family of inhibitors. This 14 amino acid cyclic peptide exhibits several features i.e. compact rigidity, well-defined structure and small size that could result in a wide range of potential applications. Some examples of engineering of the specificity of this inhibitor along with structure - activity relationships will be discussed herein. Additionally, potential uses of STFI-1 and its analogs as pharmaceutical agents will be described.
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Cite this article as:
Lesner Adam, Legowska Anna, Wysocka Magdalena and Rolka Krzysztof, Sunflower Trypsin Inhibitor 1 as a Molecular Scaffold for Drug Discovery, Current Pharmaceutical Design 2011; 17 (38) . https://dx.doi.org/10.2174/138161211798999393
DOI https://dx.doi.org/10.2174/138161211798999393 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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