Abstract
T-cell zeta chain expression, phosphorylation and degradation and their role in T-cell signal transduction and immune response regulation in health and disease. Zeta chain is a stable constituent of the antigen specific T-cell receptor and its phosphorylation is one of the earliest and key events in the T-cell signal transduction. Zeta chain phosphorylation is strictly controlled by the action of sarcomafamily kinases and also by phosphatases, indicating its crucial role in antigen specific T-cell activation. Furthermore, after its phosphorylation and T-cell activation, ζ-chain is ubiquitylated and degraded, a fact suggesting that its level on T-cell surface is also under control and contribute to the regulation of an initiated immune response. Zeta chain expression and/or phosphorylation seems to be of great importance in many clinical conditions from the pathogenesis of various types of cancer to the immunosuppressive state in dialysis patients. Its levels are also affected by chronic inflammation. In addition to its role in the antigen specific signal transduction, ζ-chain is present only in T-cells and natural killer cells, making it a possible target for immunotherapeutic applications. The recent discovery of specific inhibitors of ζ-chain phosphorylation opens new horizons for future research and for possible therapeutic interventions in various clinical conditions.
Keywords: T-cell receptor, zeta chain, cancer, autoimmune disease, infection, inflammation
Current Signal Transduction Therapy
Title: T-Cell Zeta Chain Expression, Phosphorylation and Degradation and their Role in T-Cell Signal Transduction and Immune Response Regulation in Health And Disease
Volume: 1 Issue: 2
Author(s): Theodoros Eleftheriadis, Georgia Antoniadi, Vassilios Liakopoulos and Alexandros Kortsaris
Affiliation:
Keywords: T-cell receptor, zeta chain, cancer, autoimmune disease, infection, inflammation
Abstract: T-cell zeta chain expression, phosphorylation and degradation and their role in T-cell signal transduction and immune response regulation in health and disease. Zeta chain is a stable constituent of the antigen specific T-cell receptor and its phosphorylation is one of the earliest and key events in the T-cell signal transduction. Zeta chain phosphorylation is strictly controlled by the action of sarcomafamily kinases and also by phosphatases, indicating its crucial role in antigen specific T-cell activation. Furthermore, after its phosphorylation and T-cell activation, ζ-chain is ubiquitylated and degraded, a fact suggesting that its level on T-cell surface is also under control and contribute to the regulation of an initiated immune response. Zeta chain expression and/or phosphorylation seems to be of great importance in many clinical conditions from the pathogenesis of various types of cancer to the immunosuppressive state in dialysis patients. Its levels are also affected by chronic inflammation. In addition to its role in the antigen specific signal transduction, ζ-chain is present only in T-cells and natural killer cells, making it a possible target for immunotherapeutic applications. The recent discovery of specific inhibitors of ζ-chain phosphorylation opens new horizons for future research and for possible therapeutic interventions in various clinical conditions.
Export Options
About this article
Cite this article as:
Eleftheriadis Theodoros, Antoniadi Georgia, Liakopoulos Vassilios and Kortsaris Alexandros, T-Cell Zeta Chain Expression, Phosphorylation and Degradation and their Role in T-Cell Signal Transduction and Immune Response Regulation in Health And Disease, Current Signal Transduction Therapy 2006; 1 (2) . https://dx.doi.org/10.2174/157436206777012039
DOI https://dx.doi.org/10.2174/157436206777012039 |
Print ISSN 1574-3624 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-389X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Linc01638 Promotes Tumorigenesis in HER2+ Breast Cancer
Current Cancer Drug Targets Immune Modulation of Asian Folk Herbal Medicines and Related Chemical Components for Cancer Management
Current Medicinal Chemistry Cyclooxygenases in Cancer: Chemoprevention and Sensitization to Conventional Therapies
Mini-Reviews in Medicinal Chemistry 1,4-Benzothiazines-A Biologically Attractive Scaffold
Mini-Reviews in Medicinal Chemistry Anticancer Agents Derived from Natural Products
Mini-Reviews in Medicinal Chemistry 5-Fluorouracil Derivatives Induce Differentiation Mediated by Tubulin and HLA Class I Modulation
Medicinal Chemistry Inhibiting Cyclin-Dependent Kinase / Cyclin Activity for the Treatment of Cancer and Cardiovascular Disease
Current Pharmaceutical Biotechnology Andrographolide Inhibits Osteopontin Expression and Breast Tumor Growth Through Down Regulation of PI3 Kinase/Akt Signaling Pathway
Current Molecular Medicine Potential Therapeutic Agents from the Red Sea Organisms
Medicinal Chemistry Mechanisms of Action and Chemical-Biological Interactions Between Ozone and Body Compartments: A Critical Appraisal of the Different Administration Routes
Current Drug Therapy Improving Brain Drug Targeting Through Exploitation of The Nose-to- Brain Route: A Physiological and Pharmacokinetic Perspective
Current Drug Delivery Beneficial Action of Citrus Flavonoids on Multiple Cancer-Related Biological Pathways
Current Cancer Drug Targets Pharmacogenetics of Irinotecan
Current Medicinal Chemistry - Anti-Cancer Agents CDK Inhibitors Induce Mitochondria-mediated Apoptosis Through the Activation of Polyamine Catabolic Pathway in LNCaP, DU145 and PC3 Prostate Cancer Cells
Current Pharmaceutical Design Development of Peptides as Potential Drugs for Cancer Therapy
Current Pharmaceutical Design Characterization of Cepharanthin Nanosuspensions and Evaluation of Their In Vitro Activity for the HepG2 Hepatocellular Carcinoma Cell Line
Anti-Cancer Agents in Medicinal Chemistry Should the Status of the Pathway Mediated by BRCA1 and BRCA2 be Evaluated Before Selecting Cancer Chemotherapy Drugs?
Current Pharmacogenomics Prospects of Gene Therapy for Pulmonary Diseases: Progress and Limitations
Medicinal Chemistry Multifunctional Radiolabeled Nanoparticles for Targeted Therapy
Current Medicinal Chemistry ZD6474, a Small Molecule Tyrosine Kinase Inhibitor, Potentiates the Anti-Tumor and Anti-Metastasis Effects of Radiation for Human Nasopharyngeal Carcinoma
Current Cancer Drug Targets