Abstract
Among concepts proposed to elucidate atherosclerosis process, the oxidative modification hypothesis is more considered to be investigated in studies. Based on the hypothesis, the LDL components are chemically modified due to oxidative stress within subendothelial space of vessels. The cells are able to recognize the oxidized LDL (ox-LDL) preparations so that inflammatory events spread through intracellular pathways and lead to the cellular dysfunction and the production of atherosclerotic plaques. The circulating ox-LDL level is suggested as biomarker of atherogenic lesions. However, it is not confirmed in some studies since the circulating ox-LDL clearance during the extent of atherosclerosis process is related to function of scavenger receptors and the serum anti LDL levels. The report is focused on the biochemical characteristics of modified LDL components, the cellular internalization of ox-LDL particles through the scavenger receptors, prediction of consensus blocks in the receptor sequences and the circulating ox-LDL assessments in cardiovascular complications.
Keywords: Ox-LDL, Components, Scavenger receptors, Blocks, Cardiovascular disease, Lysophosphatidylcholine, sn-2 acyl group, PAF-AH enzymes, chain-oxidized oxysterols, malondialdehyde
Cardiovascular & Hematological Disorders-Drug Targets
Title: Ox-LDL Particles: Modified Components, Cellular Uptake, Biological Roles and Clinical Assessments
Volume: 11 Issue: 2
Author(s): Mohammad Najafi, Abazar Roustazadeh and Behnam Alipoor
Affiliation:
Keywords: Ox-LDL, Components, Scavenger receptors, Blocks, Cardiovascular disease, Lysophosphatidylcholine, sn-2 acyl group, PAF-AH enzymes, chain-oxidized oxysterols, malondialdehyde
Abstract: Among concepts proposed to elucidate atherosclerosis process, the oxidative modification hypothesis is more considered to be investigated in studies. Based on the hypothesis, the LDL components are chemically modified due to oxidative stress within subendothelial space of vessels. The cells are able to recognize the oxidized LDL (ox-LDL) preparations so that inflammatory events spread through intracellular pathways and lead to the cellular dysfunction and the production of atherosclerotic plaques. The circulating ox-LDL level is suggested as biomarker of atherogenic lesions. However, it is not confirmed in some studies since the circulating ox-LDL clearance during the extent of atherosclerosis process is related to function of scavenger receptors and the serum anti LDL levels. The report is focused on the biochemical characteristics of modified LDL components, the cellular internalization of ox-LDL particles through the scavenger receptors, prediction of consensus blocks in the receptor sequences and the circulating ox-LDL assessments in cardiovascular complications.
Export Options
About this article
Cite this article as:
Najafi Mohammad, Roustazadeh Abazar and Alipoor Behnam, Ox-LDL Particles: Modified Components, Cellular Uptake, Biological Roles and Clinical Assessments, Cardiovascular & Hematological Disorders-Drug Targets 2011; 11 (2) . https://dx.doi.org/10.2174/187152911798346990
DOI https://dx.doi.org/10.2174/187152911798346990 |
Print ISSN 1871-529X |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-4063 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
GLP-1 Agonists Exenatide and Liraglutide: A Review About Their Safety and Efficacy
Current Clinical Pharmacology New non-peptidic Inhibitors of Papain Derived from Etacrynic Acid
Medicinal Chemistry The Role of Omega-3 Polyunsaturated Fatty Acids Supplementation in Childhood: A Review
Recent Patents on Cardiovascular Drug Discovery Renal Microcirculation and Calcium Channel Subtypes
Current Hypertension Reviews Synthesis, Computational Analysis, Antimicrobial, Antioxidant, Trypan Blue Exclusion Assay, β-hematin Assay and Anti-inflammatory Studies of some Hydrazones (Part-I)
Current Computer-Aided Drug Design Potential Role of microRNAs in Cardiovascular Disease: Are They up to Their Hype?
Current Cardiology Reviews Herbal Nano Formulations: Patent and Regulatory Overview
Applied Clinical Research, Clinical Trials and Regulatory Affairs Subject Index To Volume 2
Current Rheumatology Reviews Antioxidant Hybrid Compounds: A Promising Therapeutic Intervention in Oxidative Stress Induced Diseases
Mini-Reviews in Medicinal Chemistry Resveratrol and Stroke: from Chemistry to Medicine
Current Neurovascular Research Erythrocyte Associated Amyloid-β as Potential Biomarker to Diagnose Dementia
Current Alzheimer Research Beta-Blockers in Children with Congenital Heart Disease Before a Corrective Procedure
Reviews on Recent Clinical Trials Vascular Disease and Risk Factors in Chronic Kidney Disease
Vascular Disease Prevention (Discontinued) Cerebrovascular Complications of Diabetes: SGLT-2 Inhibitors as a Promising Future Therapeutics
Current Drug Targets Hypertension Impairs Cerebral Blood Flow in a Mouse Model for Alzheimer’s Disease
Current Alzheimer Research Nanocarriers in Improved Heparin Delivery: Recent Updates
Current Pharmaceutical Design Mechanisms by which Stress Affects the Experimental and Clinical Inflammatory Bowel Disease (IBD): Role of Brain-Gut Axis
Current Neuropharmacology Comparison of the Characteristics and Performance of Flurbiprofen 8.75 mg Spray for Sore Throat
Current Drug Delivery The Prognostic Effect of Clinical and Laboratory Findings on in-hospital Mortality in Patients with Confirmed COVID-19 Disease
Current Respiratory Medicine Reviews Adoptive Regulatory T-cell Therapy Attenuates Subarachnoid Hemor-rhage-induced Cerebral Inflammation by Suppressing TLR4/NF-B Signaling Pathway
Current Neurovascular Research