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Current Cardiology Reviews


ISSN (Print): 1573-403X
ISSN (Online): 1875-6557

Sepsis-induced Cardiomyopathy

Author(s): Francisco J. Romero-Bermejo, Manuel Ruiz-Bailen, Julian Gil-Cebrian and Maria J. Huertos-Ranchal

Volume 7, Issue 3, 2011

Page: [163 - 183] Pages: 21

DOI: 10.2174/157340311798220494

Price: $65


Myocardial dysfunction is one of the main predictors of poor outcome in septic patients, with mortality rates next to 70%. During the sepsis-induced myocardial dysfunction, both ventricles can dilate and diminish its ejection fraction, having less response to fluid resuscitation and catecholamines, but typically is assumed to be reversible within 7-10 days. In the last 30 years, Its being subject of substantial research; however no explanation of its etiopathogenesis or effective treatment have been proved yet. The aim of this manuscript is to review on the most relevant aspects of the sepsisinduced myocardial dysfunction, discuss its clinical presentation, pathophysiology, etiopathogenesis, diagnostic tools and therapeutic strategies proposed in recent years.

Keywords: Myocardial dysfunction, cardiac depression, heart failure, sepsis, severe sepsis, septic shock, SIMD, RMD, LVEF, Paradoxically

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