Heat Shock Protein-60 and Risk for Cardiovascular Disease

Title: Heat Shock Protein-60 and Risk for Cardiovascular Disease

Volume: 17 Issue: 33

Author(s): Manfredi Rizzo, Alberto J.L. Macario, Everly Conway de Macario, Ioanna Gouni-Berthold, Heiner K. Berthold, Giovam Battista Rini, Giovanni Zummo and Francesco Cappello

Affiliation:

Keywords: Chaperonin, heat shock protein 60, cardiomyocytes, heart failure, cardiovascular disease, atherosclerosis, apoptosis, microRNAs (miRs), diabetes, Atrial fibrillation

Abstract: Cardiovascular disease (CVD) is a leading cause of morbidity and mortality worldwide. There is growing evidence that molecular chaperones, many of which are heat shock proteins HSPs, are involved in CVD pathogenesis. In this review we focus on HSP60, the human mitochondrial chaperone that also displays extramitochondrial and extracellular functions. HSP60 is typically cytoprotective but a number of stress conditions determine its conversion to a potentially toxic molecule for cells and tissues. We present illustrative examples of specific subtypes of CVD where HSP60 is implicated in the initiation and/or progression of disease. The data not only indicate a pathogenic role for HSP60 but also its potential as a biomarker with applications for diagnosis, assessing prognosis and response to treatment, as well as for preventing and treating CVD.

Cite this article as:

Rizzo Manfredi, J.L. Macario Alberto, Conway de Macario Everly, Gouni-Berthold Ioanna, K. Berthold Heiner, Battista Rini Giovam, Zummo Giovanni and Cappello Francesco, Heat Shock Protein-60 and Risk for Cardiovascular Disease, Current Pharmaceutical Design 2011; 17 (33) . https://dx.doi.org/10.2174/138161211798220981