Role and Treatment of Mitochondrial DNA-Related Mitochondrial Dysfunction in Sporadic Neurodegenerative Diseases

Russell      H. Swerdlow

Abstract

Several sporadic neurodegenerative diseases display phenomena that directly or indirectly relate to mitochondrial function. Data suggesting altered mitochondrial function in these diseases could arise from mitochondrial DNA (mtDNA) are reviewed. Approaches for manipulating mitochondrial function and minimizing the downstream consequences of mitochondrial dysfunction are discussed.

Keywords: Cybrids, endophenotype, mitochondria, mitochondrial DNA, mitochondrial medicine, neurodegenerative disease, mutations, platelet, vitamin E, autophagy