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Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Stem Cell-Based Immunomodulation in Type 1 Diabetes: Beyond the Regenerative Approach

Author(s): Biancamaria Longoni and Franco Mosca

Volume 17, Issue 29, 2011

Page: [3229 - 3242] Pages: 14

DOI: 10.2174/138161211798157595

Price: $65


Type 1 diabetes (T1D) is an autoimmune disease, leading to pancreatic β-cell destruction and loss of glycaemic control. Administration of exogenous insulin to diabetic patients prevents life-threatening metabolic derangement, but may fail to prevent other longterm complications, such as kidney failure or diabetic retinopathy. Islet transplantation is a low-risk surgical procedure, affording improved glucose homeostasis provided sufficient islets engraft in the liver. Here we review work on the use of stem cells to generate β- cells for islet transplantation, indicating the need for improved protocols for their derivation and full maturation. We also consider recent evidence indicating that adult stem/progenitor cells may affect islet transplantation by improving the viability of engrafted islets and controlling immune reactions to islet allo- and auto-antigens, extending stem-cell use in T1D beyond the regenerative approach.

Keywords: Pancreatic islet, transplantation, autoimmunity, mesenchymal stem cells, regeneration, graft rejection, Calcium, insulin resistance, diabetes, vascular endothelial growth factor (VEGF)

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