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Protein & Peptide Letters


ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Protein-Peptide Interaction Studies Demonstrate the Versatility of Calmodulin Target Protein Binding

Author(s): Hiroaki Ishida and Hans J. Vogel

Volume 13, Issue 5, 2006

Page: [455 - 465] Pages: 11

DOI: 10.2174/092986606776819600

Price: $65


Calmodulin (CaM) is a prototypical Ca2+-sensor protein that can control many important biological functions by binding to hundreds of target proteins. To gain insight into the versatility of CaM-target recognition, we have analyzed the complex structures for many types of CaM-binding peptides and some target proteins. In particular, some recently reported novel complex structures reveal that the versatile target binding of CaM is accommodated by its flexible domain arrangement and the malleability of its interfaces.

Keywords: Calcium, calmodulin, calmodulin-binding peptide, target-protein, calmodulin-target complex, myristoylation

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