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Current Drug Targets


ISSN (Print): 1389-4501
ISSN (Online): 1873-5592

Oral Antiplatelet Therapy for Acute Coronary Syndromes: Aspirin, P2Y12 Inhibition and Thrombin Receptor Antagonists

Author(s): Alison L. Bailey and Charles L. Campbell

Volume 12 , Issue 12 , 2011

Page: [1805 - 1812] Pages: 8

DOI: 10.2174/138945011797635830

Price: $65


The platelet is central to the pathophysiology of acute coronary syndromes (ACS) via its direct participation in the formation of the thrombotic occlusion and its participation in the coagulation cascade that results in the formation of thrombin. Antiplatelet therapy is a cornerstone of therapy in the setting of ACS. Unfortunately, many patients who receive intensive antiplatelet therapy remain at high risk for recurrent events. Current efforts to reduce this “residual risk” include lifestyle modifications, cardiac rehabilitation, and intensive therapy for dyslipidemia. Also being investigated are methods of individualizing and intensifying antiplatelet therapy. Novel compounds that promise to reduce recurrent ischemic events without an increase in bleeding events are being evaluated in clinical trials. This review summarizes ongoing efforts to improve the effectiveness of antiplatelet therapy among patients with ACS.

Keywords: Antiplatelet therapy, acute coronary syndromes, coronary artery disease, residual risk, ACS, treatment, P2Y12 receptor antagonists, thrombin receptor antagonism, Vorapaxar, PAR1

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