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Current Diabetes Reviews


ISSN (Print): 1573-3998
ISSN (Online): 1875-6417

Pharmacological Management of Type 2 Diabetes Mellitus: An Update

Author(s): Samer El-Kaissi and Suphia Sherbeeni

Volume 7, Issue 6, 2011

Page: [392 - 405] Pages: 14

DOI: 10.2174/157339911797579160

Price: $65


While lifestyle modifications and metformin are the cornerstone of the initial management of type 2 diabetes mellitus, there is an increasing array of second and third-line pharmacological agents for this condition. These include sulphonylureas, insulin, thiazolidinediones and alpha-glucosidase inhibitors, with the more recent addition of glucagon- like peptide-1 agonists, dipeptidyl peptidase-IV inhibitors and pramlintide. Moreover, insulin analogues that better simulate endogenous insulin secretion have been developed. This review aims to provide an update on the current pharmacological management of type 2 diabetes mellitus, and to highlight the benefits and limitations of each treatment.

Keywords: Type 2 diabetes mellitus, Insulin, Thiazolidinediones, Sulphonylurea, Metformin, Glucagon-like peptide-1, Dipeptidyl peptidase-IV inhibitor, Bromocriptine, Alpha glucosidase inhibitor, Colesevelam

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