Abstract
Three EPMEs based on maltodextrins with different dextrose equivalent (DE) values [I (4.0-7.0), II (13.0-17.0) and III (16.5-19.5)], were designed for the determination of L-vesamicol. The linear concentration ranges of the proposed electrodes were 10-4 - 10-2 mol/L for maltodextrin I-based electrode, 10-5 -10-3 mol/L for maltodextrin II-based electrode and 10-9 - 10-7 mol/L for maltodextrin III-based electrode. The detection limits of the proposed electrodes were 1.34x10-5, 5.0x10-6 and 3.33x10-10 mol/L for maltodextrin I, II and III based electrodes, respectively. The selectivity of EPMEs for L-vesamicol was tested over D-vesamicol, creatine, creatinine and some inorganic ions. The surfaces of the electrodes can be easily renewed by simply polishing on alumina.
Keywords: Enantioselective, Potentiometric membrane electrode, Maltodextrins, L-vesamicol, Alzheimer's disease, Ag/AgCl electrode, Parkinson's disease, Down's Syndrome, Olivopontocerebellar atrophy, Electrophoresis
Current Pharmaceutical Analysis
Title: Enantioselective, Potentiometric Membrane Electrodes (EPME) Based on Maltodextrins for the Determination of L-Vesamicol in Serum Samples
Volume: 7 Issue: 4
Author(s): Raluca-Ioana Stefan-van Staden, R'afat M. Nejem, Jacobus F. van Staden and Hassan Y. Aboul-Enein
Affiliation:
Keywords: Enantioselective, Potentiometric membrane electrode, Maltodextrins, L-vesamicol, Alzheimer's disease, Ag/AgCl electrode, Parkinson's disease, Down's Syndrome, Olivopontocerebellar atrophy, Electrophoresis
Abstract: Three EPMEs based on maltodextrins with different dextrose equivalent (DE) values [I (4.0-7.0), II (13.0-17.0) and III (16.5-19.5)], were designed for the determination of L-vesamicol. The linear concentration ranges of the proposed electrodes were 10-4 - 10-2 mol/L for maltodextrin I-based electrode, 10-5 -10-3 mol/L for maltodextrin II-based electrode and 10-9 - 10-7 mol/L for maltodextrin III-based electrode. The detection limits of the proposed electrodes were 1.34x10-5, 5.0x10-6 and 3.33x10-10 mol/L for maltodextrin I, II and III based electrodes, respectively. The selectivity of EPMEs for L-vesamicol was tested over D-vesamicol, creatine, creatinine and some inorganic ions. The surfaces of the electrodes can be easily renewed by simply polishing on alumina.
Export Options
About this article
Cite this article as:
Stefan-van Staden Raluca-Ioana, M. Nejem R'afat, F. van Staden Jacobus and Y. Aboul-Enein Hassan, Enantioselective, Potentiometric Membrane Electrodes (EPME) Based on Maltodextrins for the Determination of L-Vesamicol in Serum Samples, Current Pharmaceutical Analysis 2011; 7 (4) . https://dx.doi.org/10.2174/157341211797458069
DOI https://dx.doi.org/10.2174/157341211797458069 |
Print ISSN 1573-4129 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-676X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Preventive and Protective Roles of Dietary Nrf2 Activators Against Central Nervous System Diseases
CNS & Neurological Disorders - Drug Targets Epigenetic Mechanisms in Alzheimer's Disease
Current Medicinal Chemistry Conformationally Controlled Mechanistic Aspects of BACE 1 Inhibitors
Central Nervous System Agents in Medicinal Chemistry COX-2: Friend or Foe?
Current Pharmaceutical Design Conantokins Inhibitors of Ion Flow through the N-Methyl-D-Aspartate Receptor Channels
Current Drug Targets Cystatin C in Cerebrovascular Disorders
Current Neurovascular Research β-Lactams as Neuroprotective Agents
Anti-Infective Agents in Medicinal Chemistry Predictors of Conversion to Dementia of Probable Alzheimer Type in Patients with Mild Cognitive Impairment
Current Alzheimer Research Distinctive Effects of Aerobic and Resistance Exercise Modes on Neurocognitive and Biochemical Changes in Individuals with Mild Cognitive Impairment
Current Alzheimer Research Statin Treatment Non-adherence and Discontinuation: Clinical Implications and Potential Solutions
Current Pharmaceutical Design Modification Strategies of Lipid-Based Nanocarriers for Mucosal Drug Delivery
Current Pharmaceutical Design Towards More Efficient Glutathione Peroxidase Mimics: Substrate Recognition and Catalytic Group Assembly
Current Medicinal Chemistry Optimized High-Yield Purification of Obesity-Associated Melanocortin 4 Receptor
Protein & Peptide Letters RNA Splicing Manipulation: Strategies to Modify Gene Expression for a Variety of Therapeutic Outcomes
Current Gene Therapy Targets of Antidementive Therapy: Drugs with a Specific Pharmacological Mechanism of Action
Current Pharmaceutical Design Deciphering the Role of Nanoparticle-based Treatment for Parkinson’s Disease
Current Drug Metabolism Quantitative μPET Imaging of Cerebral Glucose Metabolism and Amyloidosis in the TASTPM Double Transgenic Mouse Model of Alzheimer’s Disease
Current Alzheimer Research Telomeres, Senescence and Longevity: The Role of Oxidative Stress and Antioxidants
Current Pharmacogenomics Involvement of Cytosolic Phospholipase A2, Calcium Independent Phospholipase A2 and Plasmalogen Selective Phospholipase A2 in Neurodegenerative and Neuropsychiatric Conditions
Current Medicinal Chemistry Alzheimer's Disease: A Systemic Review of Substantial Therapeutic Targets and the Leading Multi-functional Molecules
Current Topics in Medicinal Chemistry