Abstract
Peptide aptamers are combinatorial protein molecules with specific bind affinity to given target proteins under intracellular conditions. The typical structure of peptide aptamers is a short peptide region inserted within a scaffold protein. The short peptide region is responsible for binding with its target protein and the scaffold protein helps to enhance the binding affinity and specificity through restriction on the conformation of the binding peptide. This unique structural feature allows peptide aptamers to bind with their target proteins with strong affinity and high specificity. Applications of peptide aptamers thus vary from in vitro detection of various proteins in a complex mixture to in vivo modulation on proteins and cell functions. Peptide aptamers have also been considered as therapeutic molecules because of their anticancer and antivirus activity. Due to the importance of peptide aptamers, a general review on the structure, selection and applications of peptide aptamers in biological study as well as in therapeutics will be presented in this paper.
Keywords: Peptide aptamers, target protein, protein function modulation, antivirus, anticancer, therapeutic application
Current Medicinal Chemistry
Title: Peptide Aptamers with Biological and Therapeutic Applications
Volume: 18 Issue: 27
Author(s): J. Li, S. Tan, X. Chen, C.-Y. Zhang and Y. Zhang
Affiliation:
Keywords: Peptide aptamers, target protein, protein function modulation, antivirus, anticancer, therapeutic application
Abstract: Peptide aptamers are combinatorial protein molecules with specific bind affinity to given target proteins under intracellular conditions. The typical structure of peptide aptamers is a short peptide region inserted within a scaffold protein. The short peptide region is responsible for binding with its target protein and the scaffold protein helps to enhance the binding affinity and specificity through restriction on the conformation of the binding peptide. This unique structural feature allows peptide aptamers to bind with their target proteins with strong affinity and high specificity. Applications of peptide aptamers thus vary from in vitro detection of various proteins in a complex mixture to in vivo modulation on proteins and cell functions. Peptide aptamers have also been considered as therapeutic molecules because of their anticancer and antivirus activity. Due to the importance of peptide aptamers, a general review on the structure, selection and applications of peptide aptamers in biological study as well as in therapeutics will be presented in this paper.
Export Options
About this article
Cite this article as:
Li J., Tan S., Chen X., Zhang C.-Y. and Zhang Y., Peptide Aptamers with Biological and Therapeutic Applications, Current Medicinal Chemistry 2011; 18 (27) . https://dx.doi.org/10.2174/092986711797189583
DOI https://dx.doi.org/10.2174/092986711797189583 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
Approaches to the treatment of chronic inflammation
Chronic inflammation is a hallmark of numerous diseases, significantly impacting global health. Although chronic inflammation is a hot topic, not much has been written about approaches to its treatment. This thematic issue aims to showcase the latest advancements in chronic inflammation treatment and foster discussion on future directions in this ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Comparison of Glucocorticoid Receptor- and Epigenetically Regulated Genes in Proliferating Versus Growth-Arrested Neuro-2a Cells
CNS & Neurological Disorders - Drug Targets Targeting Soluble Epoxide Hydrolase for Inflammation and Pain - An Overview of Pharmacology and the Inhibitors
Inflammation & Allergy - Drug Targets (Discontinued) Fullerenes for Applications in Biology and Medicine
Current Medicinal Chemistry Autofluorescence of Breast Cancer Proteins
Current Metabolomics The Yin and Yang of microRNA Assay Methods
MicroRNA Vitamin D/VDR, Probiotics, and Gastrointestinal Diseases
Current Medicinal Chemistry Interrelated Roles for the Aryl Hydrocarbon Receptor and Hypoxia Inducible Factor-1α in the Immune Response to Infection
Current Immunology Reviews (Discontinued) Covalently and Ionically Crosslinked Chitosan Nanogels for Drug Delivery
Current Pharmaceutical Design Biomedical Applications of Carbon Nanotubes: A Critical Review
Current Drug Delivery Current Biological Therapies for Inflammatory Bowel Disease
Current Pharmaceutical Design Recent Patents on Liposomal-Based Chemotherapeutics with a Triggered Release Mechanism
Recent Patents on Nanomedicine Hydroxysteroid Dehydrogenase (17β -HSD3, 17β-HSD5, and 3α-HSD3) Inhibitors:Extragonadal Regulation of Intracellular Sex Steroid Hormone Levels
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery Carbon Nano Tubes: Novel Drug Delivery System in Amelioration of Alzheimer’s Disease
Combinatorial Chemistry & High Throughput Screening Chemokines and Chemokine Receptors: Potential Therapeutic Targets in Multiple Sclerosis
Current Drug Targets - Inflammation & Allergy Design of Fucoidan Functionalized - Iron Oxide Nanoparticles for Biomedical Applications
Current Drug Delivery Natural Products as Aromatase Inhibitors
Anti-Cancer Agents in Medicinal Chemistry Advanced Assessment of the Endogenous Hormone Level as a Potential Biomarker of the Urogenital Tract Cancer
Combinatorial Chemistry & High Throughput Screening Mouse Models of Autoimmune Uveitis
Current Pharmaceutical Design Entosis and Related Forms of Cell Death within Cells.
Current Molecular Medicine The Pathophysiological Role of PEDF in Bone Diseases
Current Molecular Medicine