Abstract
Aptamers are nonnaturally occurring oligonucleotides generated by the SELEX (Systematic Evolution of Ligands by Exponential enrichment) process. Due to their unique three-dimensional structures, aptamers can bind to various targets, ranging from small compounds to cells and tissues, with high affinity and specificity. While first reported in 1990, aptamers have become useful tools in the biomedical field because of their unique characteristics, such as easy and quick preparation, cost-effectiveness, small size, versatility, et al. Recently various chemical modifications have been introduced to enhance aptamer's stability in the body fluids and their bioavailability in animals, which have pushed aptamer closer to therapeutic and diagnostic application. This review provides an overview of the aptamer modifications and their application in the nervous system disorders.
Keywords: Aptamer, SELEX, chemical modification, the nervous system, prion disease, Alzheimer's disease, myasthenia gravis, brain tumor
Current Medicinal Chemistry
Title: Aptamers: Selection, Modification and Application to Nervous System Diseases
Volume: 18 Issue: 27
Author(s): Y. Yang, X. Ren, H. J. Schluesener and Z. Zhang
Affiliation:
Keywords: Aptamer, SELEX, chemical modification, the nervous system, prion disease, Alzheimer's disease, myasthenia gravis, brain tumor
Abstract: Aptamers are nonnaturally occurring oligonucleotides generated by the SELEX (Systematic Evolution of Ligands by Exponential enrichment) process. Due to their unique three-dimensional structures, aptamers can bind to various targets, ranging from small compounds to cells and tissues, with high affinity and specificity. While first reported in 1990, aptamers have become useful tools in the biomedical field because of their unique characteristics, such as easy and quick preparation, cost-effectiveness, small size, versatility, et al. Recently various chemical modifications have been introduced to enhance aptamer's stability in the body fluids and their bioavailability in animals, which have pushed aptamer closer to therapeutic and diagnostic application. This review provides an overview of the aptamer modifications and their application in the nervous system disorders.
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Cite this article as:
Yang Y., Ren X., J. Schluesener H. and Zhang Z., Aptamers: Selection, Modification and Application to Nervous System Diseases, Current Medicinal Chemistry 2011; 18 (27) . https://dx.doi.org/10.2174/092986711797189646
DOI https://dx.doi.org/10.2174/092986711797189646 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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