Generic placeholder image

Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Gas Bioengineering Using Hemoglobin-Vesicles For Versatile Clinical Applications

Author(s): Hiromi Sakai, Shinji Takeoka and Koichi Kobayashi

Volume 17, Issue 22, 2011

Page: [2352 - 2359] Pages: 8

DOI: 10.2174/138161211797052637

Price: $65


Blood transfusion systems have greatly benefited human health and welfare. Nevertheless, some problems remain: possibility of infection, blood type mismatching, immunological response, and a short shelf life that is insufficient for stockpiling for emergency situations. Realization of artificial O2 carriers is anticipated to solve such problems. During the long development of hemoglobin (Hb)-based O2 carriers, many side effects of cell-free Hb molecules have arisen, and have implied the physiological importance of the cellular structure of red blood cells (RBCs). Therefore, Hb-vesicles (HbVs) have been developed as artificial red cells that encapsulate a concentrated Hb solution in thin lipid bilayer vesicles. This Hb encapsulation can shield various toxic effects of molecular Hbs, especially reactions with endogenous NO and CO as vasorelaxation factors. Physicochemical analyses have clarified that Hb encapsulation retards these gaseous reactions significantly. “Gas Bioengineering” is intended to create systems using bioengineering and chemical engineering techniques to facilitate the transport of or regulate the concentration of endogenous or exogenous gaseous molecules (such as O2, NO, and CO) that are sometimes vital and sometimes toxic to humans. Gas bioengineering using HbVs underscores the potential of HbVs as a transfusion alternative and promises its use for other clinical applications that remain unattainable using RBC transfusion.

Keywords: Blood substitutes, liposome, hemodynamics, microcirculation, resuscitative fluid, vasoconstriction, hemorrhagic shock, macrophages, microvessels, ischemia-reperfusion

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy