Design of Magnetic Nanoparticles-Assisted Drug Delivery System

Guo-Jing      Chen; Li-Fang      Wang

Abstract

Magnetic nanoparticles (MNPs) have been designed for multifaceted applications such as contrast agents in magnetic resonance imaging (MRI) diagnosis, drug/gene carriers for different kinds of therapeutic agents, tissue repair, hyperthermia, immunoassay, and cell separation/sensing. This review highlights synthesis methods, stabilizers used for surface coating on MNPs, and target ligands for ferrying payloads to an interested disease area. Some of the recent biomedical applications of MNPs in the field of drug and DNA targeting delivery are extensively reviewed.

Keywords: Nanotechnology, magnetic nanoparticles, superparamagnetic iron oxide, surface modification, targeting therapy, drug delivery, stabilizers, sol-gel technique, Monoclonal antibodies, magnetic field