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Reviews on Recent Clinical Trials


ISSN (Print): 1574-8871
ISSN (Online): 1876-1038

Dendritic Cell Immunotherapy for Melanoma

Author(s): Judy C. Peng, Ranjeny Thomas and Keith Dredge

Volume 1, Issue 2, 2006

Page: [87 - 102] Pages: 16

DOI: 10.2174/157488706776876517

Price: $65


Dendritic cells (DC) are the most potent antigen-presenting cells that initiate T cell-mediated immune responses against cancer. It has been almost a decade since the first trial of DC-based cancer immunotherapy was published. Despite the many clinical trials conducted since, few solid conclusions have been reached, and no specificimmunotherapy has routinely demonstrated meaningful anti-tumour responses. Clinical-grade DC can be obtained from three distinct cell populations in the blood - monocytes, CD34+ progenitors or direct isolation of circulating blood DC. This review discusses the science behind DC-based cancer immunotherapy, with a particular emphasis on the use of monocyte-derived DC in melanoma clinical trials, and the various potential avenues for improvement of patient clinical response rates.

Keywords: Dendritic cells, Cancer immunotherapy, Melanoma, Clinical trials

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