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Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

The Uniqueness of the Trypanosoma cruzi Mitochondrion: Opportunities to Target New Drugs Against Chagas Disease

Author(s): Lisvane Silva Paes, Brian Suarez Mantilla, Maria Julia Barison, Carsten Wrenger and Ariel Mariano Silber

Volume 17, Issue 20, 2011

Page: [2074 - 2099] Pages: 26

DOI: 10.2174/138161211796904786

Price: $65

Abstract

Trypanosoma cruzi is the causative agent of Chagas disease, which affects some 8 - 10 million people in the Americas. The only two drugs approved for the etiological treatment of the disease in humans were launched more than 40 years ago and have serious drawbacks. In the present work, we revisit the unique characteristics of T. cruzi mitochondria and mitochondrial metabolism. The possibility of taking advantage of these peculiarities to target new drugs against this parasite is also discussed.

Keywords: Trypanosoma cruzi, mitochondria, metabolism, bioenergetics, oxidative stress, chemotherapy, phagocytosis, Topoisomerases, endonucleases, exonucleases


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