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Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Mitochondrial Therapeutics for Cardioprotection

Author(s): Raquel S. Carreira, Pamela Lee and Roberta A. Gottlieb

Volume 17, Issue 20, 2011

Page: [2017 - 2035] Pages: 19

DOI: 10.2174/138161211796904777

Price: $65


Mitochondria represent approximately one-third of the mass of the heart and play a critical role in maintaining cellular function- however, they are also a potent source of free radicals and pro-apoptotic factors. As such, maintaining mitochondrial homeostasis is essential to cell survival. As the dominant source of ATP, continuous quality control is mandatory to ensure their ongoing optimal function. Mitochondrial quality control is accomplished by the dynamic interplay of fusion, fission, autophagy, and mitochondrial biogenesis. This review examines these processes in the heart and considers their role in the context of ischemia-reperfusion injury. Interventions that modulate mitochondrial turnover, including pharmacologic agents, exercise, and caloric restriction are discussed as a means to improve mitochondrial quality control, ameliorate cardiovascular dysfunction, and enhance longevity.

Keywords: Autophagy, caloric restriction, cardioprotection, exercise, ischemia-reperfusion, mitochondria, mitochondrial turnover, preconditioning, glycolysis, mitophagy

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