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Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Mitochondrial Drug Targets in Cell Death and Cancer

Author(s): Gustavo Ferrin, Clara I. Linares and Jordi Muntane

Volume 17, Issue 20, 2011

Page: [2002 - 2016] Pages: 15

DOI: 10.2174/138161211796904803

Price: $65


Mitochondria are involved in different physiological and pathological processes that are crucial for tumor cell physiology, growth and survival. Since cancer cells have frequently disrupted different cell death pathways that promote their survival, mitochondria may be key organelles to promote cell death in cancer cells. The present review is focused on the different experimental and therapeutic cancer strategies addressed to either target mitochondria directly, or use mitochondria as mediators of apoptosis. While the first group includes drugs that act on glycolysis, β-oxidation, electron transport chain, mitochondrial permeability and the Bcl-2/IAP family protein, the second one consists of those drugs that cause cell death through the intrinsic apoptosis pathway by promoting ROS generation or by modulating mitochondrial protein involved in apoptosis induction.

Keywords: Apoptosis, metabolism, oxidative stress, therapy, anti-tumoral therapy, cardiolipin, DNA fragmentation, Vitamin E, caspases, glycolysis

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