Abstract
There is pressing need to better understand pharmacokinetics in critically ill patients. This will aid clinicians in selecting optimal dosing regimens. Pharmacokinetic studies are difficult in this population due to the heterogeneity of the patients and the practical issues of research involving critically ill patients. Therapeutic drug monitoring is routinely performed to guide dosing for aminoglycoside and glycopeptide antibiotics. Expanding its use to other drug classes could provide new therapeutic advantages. Plasma concentration may not always reflect tissue distribution in critically ill patients. Microdialysis is a technique that can be applied in the Intensive Care Unit to measure tissue concentrations and provide further insights to antimicrobial therapy for critically ill patients. Finally, the application of population pharmacokinetic analysis in studies in critically ill patients may identify factors affecting pharmacokinetics and enhance drug dosing regimens for varied patient groups.
Keywords: Critically ill patient, microdialysis, pharmacodynamics, physiology, population pharmacokinetics, therapeutic drug monitoring., Intensive Care Unit, glycopeptide antibiotics, enhance drug dosing regimens, pharmacodynamic properties, optimal drug dosage, large variability exists, patient's clinical management, bioanalytical method
Current Pharmaceutical Biotechnology
Title: How to Measure Pharmacokinetics in Critically Ill Patients?
Volume: 12 Issue: 12
Author(s): Xin Liu, Peter S. Kruger and Michael S. Roberts
Affiliation:
Keywords: Critically ill patient, microdialysis, pharmacodynamics, physiology, population pharmacokinetics, therapeutic drug monitoring., Intensive Care Unit, glycopeptide antibiotics, enhance drug dosing regimens, pharmacodynamic properties, optimal drug dosage, large variability exists, patient's clinical management, bioanalytical method
Abstract: There is pressing need to better understand pharmacokinetics in critically ill patients. This will aid clinicians in selecting optimal dosing regimens. Pharmacokinetic studies are difficult in this population due to the heterogeneity of the patients and the practical issues of research involving critically ill patients. Therapeutic drug monitoring is routinely performed to guide dosing for aminoglycoside and glycopeptide antibiotics. Expanding its use to other drug classes could provide new therapeutic advantages. Plasma concentration may not always reflect tissue distribution in critically ill patients. Microdialysis is a technique that can be applied in the Intensive Care Unit to measure tissue concentrations and provide further insights to antimicrobial therapy for critically ill patients. Finally, the application of population pharmacokinetic analysis in studies in critically ill patients may identify factors affecting pharmacokinetics and enhance drug dosing regimens for varied patient groups.
Export Options
About this article
Cite this article as:
Liu Xin, S. Kruger Peter and S. Roberts Michael, How to Measure Pharmacokinetics in Critically Ill Patients?, Current Pharmaceutical Biotechnology 2011; 12 (12) . https://dx.doi.org/10.2174/138920111798808239
DOI https://dx.doi.org/10.2174/138920111798808239 |
Print ISSN 1389-2010 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4316 |
Call for Papers in Thematic Issues
Artificial Intelligence in Bioinformatics
Bioinformatics is an interdisciplinary field that analyzes and explores biological data. This field combines biology and information system. Artificial Intelligence (AI) has attracted great attention as it tries to replicate human intelligence. It has become common technology for analyzing and solving complex data and problems and encompasses sub-fields of machine ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Optimising the Use of Non-Invasive Ventilation in the Intensive Care Setting
Current Respiratory Medicine Reviews Recent Patents on Biomedical Applications for the Treatment of Atherosclerosis
Recent Patents on Regenerative Medicine Vascular Endothelial Growth Factor (VEGF) Signaling in Tumour Vascularization: Potential and Challenges
Current Vascular Pharmacology Transmission, Prevention and Therapeutic Strategies for COVID-19: Updates and Challenges
Coronaviruses Angiogenesis Inhibitors: Implications for Combination with Conventional Therapies
Current Pharmaceutical Design Alefacept
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Pulmonary Hypertension in the Critically Ill
Current Hypertension Reviews Recent Advances in Protein and Peptide Drug Delivery Systems
Current Drug Delivery Pulmonary Circulation and Pulmonary Function in Neonatal Lung Hypoplasia:Treatment with Corticosteroids
Current Pediatric Reviews Periodontal Disease and Periodontal Tissue Regeneration
Current Stem Cell Research & Therapy Vitamin D Insufficiency and Diabetes Risks
Current Drug Targets Alcohol Abuse, Immunosuppression, and Pulmonary Infection
Current Drug Abuse Reviews The Delivery of Personalised, Precision Medicines <i>via</i> Synthetic Proteins
Drug Delivery Letters Perspective of Molecular Hydrogen in the Treatment of Sepsis
Current Pharmaceutical Design Role of CNS Transporters in the Pharmacotherapy of HIV-1 Associated Neurological Disorders
Current Pharmaceutical Design Possible Exploitation of Non-Neuronal and Non-Chemical Synaptic Signalling Pathways in Epilepsy Therapy
Current Signal Transduction Therapy Disposition of Flavonoids Impacts their Efficacy and Safety
Current Drug Metabolism Reactive Oxygen and Nitrogen Species in the Renal Ischemia/Reperfusion Injury
Current Pharmaceutical Design Review of the Relationship between Renal and Retinal Microangiopathy in Diabetes Mellitus Patients
Current Diabetes Reviews Systemic Adverse Drug Reactions Secondary to Anti-VEGF Intravitreal Injection in Patients with Neovascular Age-Related Macular Degeneration
Current Vascular Pharmacology