Coumarins as Antioxidants

I.      Kostova; S.      Bhatia; P.      Grigorov; S.      Balkansky; V.      S. Parmar; A.      K. Prasad; L.      Saso

Abstract

Coumarins, a well-known class of naturally occurring compounds, display a remarkable array of biochemical and pharmacological actions, some of which suggest that certain members of this group of compounds may significantly affect the function of various mammalian cellular systems. The development of coumarins as antioxidant agents has attracted much attention in recent years. Coumarins afford an opportunity for the discovery of new antioxidants with truly novel mechanisms of action. This review updates and expands the 2006 review by the same author. The review considers and incorporates the most recently published literature on coumarins as related to their antioxidant properties. A lot of coumarins have been identified from natural sources, especially green plants. These natural compounds have served as valuable leads for further design and synthesis of more active analogues. Beyond doubt, a deep understanding of the mechanisms of existing synthetic and natural coumarins will build the basis for the rational design.

Keywords: antioxidants, Synthetic and natural coumarins, Coumarins, mammalian cellular system, active analogues, existing synthetic, metabolic processes, superoxide anion, hypochlorous