Generic placeholder image

Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Exploring Pharmacological Significance of Chalcone Scaffold: A Review

Author(s): N. K. Sahu, S. S. Balbhadra, J. Choudhary and D. V. Kohli

Volume 19, Issue 2, 2012

Page: [209 - 225] Pages: 17

DOI: 10.2174/092986712803414132

Price: $65


Chalcones (1,3-diaryl-2-propen-1-ones) and their heterocyclic analogues, belong to the flavonoid family, which possess a number of interesting biological properties such as antioxidant, cytotoxic, anticancer, antimicrobial, antiprotozoal, antiulcer, antihistaminic and anti-inflammatory activities. Several pure chalcones have been approved for clinical use or tested in humans. Clinical trials have shown that these compounds reached reasonable plasma concentration and are well-tolerated. For this reason they are an object of continuously growing interest amongst the scientists. However, much of the pharmacological potential of chalcones is still not utilized. The purpose of this review is to provide an overview of the pharmacological activity of naturally occurring and synthetic chalcones. This review highlights more recent pharmacological screening of these compounds, their mechanisms of action and relevant structure-activity relationships.

Keywords: Licochalcone, chalcone, α,β-unsaturated ketone, xanthohumol, butein, antimalarial, anticancer activity, pharmacological screening, biological, isoflavonoids

Rights & Permissions Print Export Cite as
© 2023 Bentham Science Publishers | Privacy Policy