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Current Psychiatry Reviews


ISSN (Print): 1573-4005
ISSN (Online): 1875-6441

Omega-3 Fatty Acids: Role in the Prevention and Treatment of Psychiatric Disorders

Author(s): Emmanuel Tsalamanios, Amalia E. Yanni and Christina Koutsari

Volume 2, Issue 2, 2006

Page: [215 - 234] Pages: 20

DOI: 10.2174/157340006776875969

Price: $65


The purpose of this article is to review the current literature regarding the role of omega-3 (ω-3) fatty acids (mainly eicosapentaenoic acid and docosahexaenoic acid) in the etiology and treatment of psychiatric disorders. Omega-3 fatty acids are essential for normal structure and function of neuronal membranes. They also influence cell signaling and are precursors to the eicosanoids, which play important regulatory roles in a wide range of physiological functions. There has been considerable interest in the potential use of ω-3 fatty acids for the treatment of psychiatric disorders including depression, bipolar disorder, schizophrenia, borderline disorder, obsessive compulsive disorder and childhood developmental and psychiatric disorders. This article provides a critical review of the recent findings and discusses future directions and questions that remain unanswered.

Keywords: Schizophrenia, Phospholipid Metabolism, magnetic resonance spectroscopy (MRS), phosphomonoesters, mitogen-activated protein kinase (MAPK), Bipolar Disorder, Depression

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