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Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

The Potential Interest of Topiramate in Addictions

Author(s): Gabriel Thorens, Joel Billieux, Rita Manghi, Riaz Khan, Yasser Khazaal and Daniele Fabio Zullino

Volume 17, Issue 14, 2011

Page: [1410 - 1415] Pages: 6

DOI: 10.2174/138161211796150864

Price: $65


Topiramate is one of the currently most promising compounds in the field of addiction medicine. This paper discusses its potential utility related to a phase model of addiction development, focusing on the assumption that addiction is a continuous process involving different neurobiological pathways, depending on the stage of addiction. A specific emphasis will be made on the development of dysfunctional automatic behaviors in the late stage of addiction and the central role of glutamate and AMPA receptors. The aim is to propose that if too broad an effect of anti-addiction medication is expected (such as anti-craving, anti-relapse and preventive effects), the results might be disappointing. The speculative specific efficacy of topiramate in addiction is described.

Keywords: Topiramate, addictions, treatment, drug abuse, dysfunctional, hedonic, ritualized, amphetamines, morphine, naltrexone, mesolimbic, synaptic, neuroanatomical, vaccines, ethanol, sensitization, kainate

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