Abstract
Hypoxia-ischemia is responsible for a high morbidity and mortality rate, both in infant and adult patients. In humans, the brain is immature from fetal to postnatal life, demonstrating more specific vulnerability than the adult one, induced by exposure at perinatal asphyxia. The extension and distribution of brain lesions depend to a large extent on the intensity and exposure to injury, the maturational stage, the affected brain region and the survival time of the patient. Different cellular events are developed in response to hypoxic-ischemic injury. These events have been related to the excitotoxicity (activation of glutamate receptors), energy failure (decrease in ATP levels), inflammatory cascade (delivery of inflammatory mediators), and gene and transcriptional activation.
Keywords: Hipoxia-Ischemia, Perinatal asphyxia, Brain damage, Excitotoxicity
Current Pediatric Reviews
Title: Cellular Mechanisms in Perinatal Hypoxic-Ischemic Brain Injury
Volume: 2 Issue: 2
Author(s): Enrique Hilario, Antonia Alvarez, Francisco J. Alvarez, Elena Gastiasoro and Adolf Valls-i-Soler
Affiliation:
Keywords: Hipoxia-Ischemia, Perinatal asphyxia, Brain damage, Excitotoxicity
Abstract: Hypoxia-ischemia is responsible for a high morbidity and mortality rate, both in infant and adult patients. In humans, the brain is immature from fetal to postnatal life, demonstrating more specific vulnerability than the adult one, induced by exposure at perinatal asphyxia. The extension and distribution of brain lesions depend to a large extent on the intensity and exposure to injury, the maturational stage, the affected brain region and the survival time of the patient. Different cellular events are developed in response to hypoxic-ischemic injury. These events have been related to the excitotoxicity (activation of glutamate receptors), energy failure (decrease in ATP levels), inflammatory cascade (delivery of inflammatory mediators), and gene and transcriptional activation.
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Cite this article as:
Hilario Enrique, Alvarez Antonia, Alvarez J. Francisco, Gastiasoro Elena and Valls-i-Soler Adolf, Cellular Mechanisms in Perinatal Hypoxic-Ischemic Brain Injury, Current Pediatric Reviews 2006; 2 (2) . https://dx.doi.org/10.2174/157339606776894667
DOI https://dx.doi.org/10.2174/157339606776894667 |
Print ISSN 1573-3963 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6336 |
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