Abstract
Methods of preparing 1,1-bi-2-naphthol (BINOL) in optically active form, are reviewed. Preparation of this compound and its derivatives through both resolution and asymmetric synthesis, are discussed. Methods of determining the enantiomeric excess of samples of optically active BINOL, both through chromatographic and spectroscopic means, are also reviewed.
Keywords: BINOL, asymmetric synthesis, resolution, enantiomeric excess
Current Organic Synthesis
Title: Preparation and Enantiomeric Excess Determination of Optically Active BINOL and BINOL Derivatives
Volume: 3 Issue: 2
Author(s): Brian E. Love
Affiliation:
Keywords: BINOL, asymmetric synthesis, resolution, enantiomeric excess
Abstract: Methods of preparing 1,1-bi-2-naphthol (BINOL) in optically active form, are reviewed. Preparation of this compound and its derivatives through both resolution and asymmetric synthesis, are discussed. Methods of determining the enantiomeric excess of samples of optically active BINOL, both through chromatographic and spectroscopic means, are also reviewed.
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Cite this article as:
Love E. Brian, Preparation and Enantiomeric Excess Determination of Optically Active BINOL and BINOL Derivatives, Current Organic Synthesis 2006; 3 (2) . https://dx.doi.org/10.2174/157017906776819178
DOI https://dx.doi.org/10.2174/157017906776819178 |
Print ISSN 1570-1794 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6271 |
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